We specialize in pioneering new sequencing technologies based on various next-generation sequencing methods. This encompasses short-read sequencing such as Illumina, long-read sequencing like Oxford Nanopore and PacBio, as well as single-cell-based technologies including 10x Genomics. Our objective is to delve into genome analysis with enhanced depth, accuracy, accessibility, and comprehensiveness. Moreover, we integrate these sequencing advancements with genome engineering technologies to elucidate the dynamics of cellular state alterations.

Single-cell sequencing is a cutting-edge technique that allows researchers to analyze the genetic information of individual cells within a heterogeneous population. Unlike traditional bulk sequencing methods, which provide an average of the genetic material from a large group of cells, single-cell sequencing enables the study of cellular diversity and heterogeneity at a granular level. Combined with CRISPR screening, referred to as "Single-cell CRISPR screen", we can analyze the heterogeneity between differentially engineered cells. 

Long-read sequencing stands as a groundbreaking advancement in genomic technology. By producing reads spanning up to millions of base pairs, it surpasses the limitations of traditional short-read sequencing methods. This enables direct measurement of single-cell level genotype and transcript isoform which was not possible with short-read sequencing. We leverage long-read sequencing to push the boundaries of genomic exploration and innovation.